Drug Information

Drug General Information
Drug ID
D0VH8A
Former ID
DNC006865
Drug Name
N-(4-(3-(pyridin-2-yl)acryloyl)phenyl)acetamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528428]
Structure
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2D MOL

3D MOL
Formula
C16H14N2O2
Canonical SMILES
CC(=O)NC1=CC=C(C=C1)C(=O)C=CC2=CC=CC=N2
InChI
1S/C16H14N2O2/c1-12(19)18-15-7-5-13(6-8-15)16(20)10-9-14-4-2-3-11-17-14/h2-11H,1H3,(H,18,19)/b10-9+
InChIKey
LAXKVXCZXLEVKG-MDZDMXLPSA-N
PubChem Compound ID
6114166
Target and Pathway
Target(s) Tubulin beta-2 chain Target Info Inhibitor [528428]
Tubulin beta Target Info Inhibitor [528428]
KEGG Pathway Phagosome
Gap junction
Pathogenic Escherichia coli infection
NetPath Pathway FSH Signaling Pathway
TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Cytoskeletal regulation by Rho GTPase
Huntington disease
Reactome Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Anchoring of the basal body to the plasma membrane
WikiPathways Parkin-Ubiquitin Proteasomal System pathway
Pathogenic Escherichia coli infection
Mitotic G2-G2/M phases
References
Ref 528428J Med Chem. 2006 Sep 21;49(19):5664-70.Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.
Ref 528428J Med Chem. 2006 Sep 21;49(19):5664-70.Design and biological evaluation of novel tubulin inhibitors as antimitotic agents using a pharmacophore binding model with tubulin.

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