Drug General Information
Drug ID	D05ZTI
Former ID	DNC011621
Drug Name	3-Hydroxy-benzamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534774]
Structure		Download 2D MOL 3D MOL
Formula	C7H7NO2
Canonical SMILES	C1=CC(=CC(=C1)O)C(=O)N
InChI	1S/C7H7NO2/c8-7(10)5-2-1-3-6(9)4-5/h1-4,9H,(H2,8,10)
InChIKey	NGMMGKYJUWYIIG-UHFFFAOYSA-N
PubChem Compound ID	342403
Target and Pathway
Target(s)	Poly [ADP-ribose] polymerase-1	Target Info	Inhibitor	[534774]
KEGG Pathway	Base excision repair
	NF-kappa B signaling pathway
PANTHER Pathway	FAS signaling pathway
Pathway Interaction Database	Integrin-linked kinase signaling
	Caspase Cascade in Apoptosis
	Notch-mediated HES/HEY network
Reactome	Dual Incision in GG-NER
WikiPathways	FAS pathway and Stress induction of HSP regulation
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Nanoparticle triggered regulated necrosis
	Corticotropin-releasing hormone
References
Ref 534774	J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774	J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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