Drug Information

Drug General Information
Drug ID
D03TNE
Former ID
DNC008054
Drug Name
N7-hydroxy-2-methoxy-N1-phenylheptanediamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529062]
Structure
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2D MOL

3D MOL
Formula
C14H20N2O4
Canonical SMILES
COC(CCCCC(=O)NO)C(=O)NC1=CC=CC=C1
InChI
1S/C14H20N2O4/c1-20-12(9-5-6-10-13(17)16-19)14(18)15-11-7-3-2-4-8-11/h2-4,7-8,12,19H,5-6,9-10H2,1H3,(H,15,18)(H,16,17)
InChIKey
GTYJNCDOILRMGX-UHFFFAOYSA-N
PubChem Compound ID
25065710
Target and Pathway
Target(s) Histone deacetylase 2 Target Info Inhibitor [529062]
KEGG Pathway Cell cycle
Notch signaling pathway
Thyroid hormone signaling pathway
Huntington's disease
Alcoholism
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Chronic myeloid leukemia
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class I
Regulation of Telomerase
Glucocorticoid receptor regulatory network
Direct p53 effectors
Hedgehog signaling events mediated by Gli proteins
Regulation of nuclear beta catenin signaling and target gene transcription
Reactome p75NTR negatively regulates cell cycle via SC1
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
HDACs deacetylate histones
NoRC negatively regulates rRNA expression
RNA Polymerase I Transcription Initiation
Factors involved in megakaryocyte development and platelet production
WikiPathways Notch Signaling Pathway
Notch Signaling Pathway
Neural Crest Differentiation
Signalling by NGF
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
Factors involved in megakaryocyte development and platelet production
Cell Cycle
References
Ref 529062Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. Epub 2007 Sep 8.Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.
Ref 529062Bioorg Med Chem Lett. 2007 Nov 15;17(22):6261-5. Epub 2007 Sep 8.Omega-alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: a study of chain-length and stereochemical dependence.

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