Drug Information

Drug General Information
Drug ID
D0J3NX
Former ID
DNC009770
Drug Name
N-cyclopentyl-6-(2-phenylethynyl)nicotinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530138]
Structure
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2D MOL

3D MOL
Formula
C19H18N2O
Canonical SMILES
C1CCC(C1)NC(=O)C2=CN=C(C=C2)C#CC3=CC=CC=C3
InChI
1S/C19H18N2O/c22-19(21-18-8-4-5-9-18)16-11-13-17(20-14-16)12-10-15-6-2-1-3-7-15/h1-3,6-7,11,13-14,18H,4-5,8-9H2,(H,21,22)
InChIKey
GKYRUZWYDPUSOV-UHFFFAOYSA-N
PubChem Compound ID
44224196
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Inhibitor [530138]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 530138Bioorg Med Chem Lett. 2009 Jun 15;19(12):3275-8. Epub 2009 Apr 24.Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
Ref 530138Bioorg Med Chem Lett. 2009 Jun 15;19(12):3275-8. Epub 2009 Apr 24.Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.

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