Drug Information

Drug General Information
Drug ID
D07TKG
Former ID
DNC001048
Drug Name
NSC 665564
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537969]
Structure
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2D MOL

3D MOL
Formula
C19H17BrN2O
Canonical SMILES
CC(=O)N1CCC2=C(C1C3=CC=CC=C3)NC4=C2C=C(C=C4)Br
InChI
1S/C19H17BrN2O/c1-12(23)22-10-9-15-16-11-14(20)7-8-17(16)21-18(15)19(22)13-5-3-2-4-6-13/h2-8,11,19,21H,9-10H2,1H3
InChIKey
CBMFCUHTQKAALP-UHFFFAOYSA-N
PubChem Compound ID
380161
PubChem Substance ID
511221, 5270437, 10272070, 11426980, 15027874, 80008797, 104583433, 117390779, 137886518, 227047688, 242537873, 246063479
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [537969]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 537969Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar. Biochem Biophys Res Commun. 1996 Jun 25;223(3):654-9.
Ref 537969Identification of a novel inhibitor (NSC 665564) of dihydroorotate dehydrogenase with a potency equivalent to brequinar. Biochem Biophys Res Commun. 1996 Jun 25;223(3):654-9.

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