Drug Information

Drug General Information
Drug ID
D0F8VS
Former ID
DNC002586
Drug Name
L-Homoarginine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C7H16N4O2
Canonical SMILES
C(CCN=C(N)N)CC(C(=O)O)N
InChI
1S/C7H16N4O2/c8-5(6(12)13)3-1-2-4-11-7(9)10/h5H,1-4,8H2,(H,12,13)(H4,9,10,11)/t5-/m0/s1
InChIKey
QUOGESRFPZDMMT-YFKPBYRVSA-N
PubChem Compound ID
9085
PubChem Substance ID
5030, 14769722, 29227701, 49989438, 53776976, 57325418, 77308586, 93374632, 98561585, 103725626, 103826209, 104163949, 104319516, 111677876, 117541449, 118313738, 119503065, 126523470, 129077328, 132564670, 134974445, 135610090, 137477441, 144079913, 152033900, 160789157, 160967042, 162181412, 162760459, 163387680, 164833490, 179316022, 184538601, 184611430, 186002908, 204370176, 204940000, 223535756, 223740029, 226427748, 249855606, 250134940, 250167553, 250198542, 252069777, 252225117, 252313808, 252350683, 252405157
Target and Pathway
Target(s) Nitric-oxide synthase, endothelial Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cycle
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathway
NetPath Pathway Wnt Signaling Pathway
PANTHER Pathway Angiogenesis
Endothelin signaling pathway
Interleukin signaling pathway
PI3 kinase pathway
VEGF signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
SHP2 signaling
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
Reactome ROS production in response to bacteria
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeability
WikiPathways ACE Inhibitor Pathway
EGF/EGFR Signaling Pathway
Myometrial Relaxation and Contraction Pathways
JAK/STAT
Corticotropin-releasing hormone
AGE/RAGE pathway
Endothelin Pathways
Leptin signaling pathway
Effects of Nitric Oxide
Metabolism of nitric oxide
Angiogenesis
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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