Drug Information

Drug General Information
Drug ID
D00WMC
Former ID
DNC009389
Drug Name
N-(4-Phenylthiazol-2-yl)isonicotinamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529901]
Structure
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2D MOL

3D MOL
Formula
C15H11N3OS
Canonical SMILES
C1=CC=C(C=C1)C2=CSC(=N2)NC(=O)C3=CC=NC=C3
InChI
1S/C15H11N3OS/c19-14(12-6-8-16-9-7-12)18-15-17-13(10-20-15)11-4-2-1-3-5-11/h1-10H,(H,17,18,19)
InChIKey
PUUUVNHZQJNJSV-UHFFFAOYSA-N
PubChem Compound ID
790259
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [529901]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.
Ref 529901J Med Chem. 2009 Feb 12;52(3):718-25.Design, synthesis, and cytoprotective effect of 2-aminothiazole analogues as potent poly(ADP-ribose) polymerase-1 inhibitors.

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