Drug Information

Drug General Information
Drug ID
D0WO3P
Former ID
DNC011717
Drug Name
2-(4-Azido-phenyl)-8-methoxy-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534774]
Structure
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2D MOL

3D MOL
Formula
C15H11N5O2
Canonical SMILES
COC1=CC=CC2=C1NC(=NC2=O)C3=CC=C(C=C3)N=[N+]=[N-]
InChI
1S/C15H11N5O2/c1-22-12-4-2-3-11-13(12)17-14(18-15(11)21)9-5-7-10(8-6-9)19-20-16/h2-8H,1H3,(H,17,18,21)
InChIKey
BLVUCZJFMHXSJA-UHFFFAOYSA-N
PubChem Compound ID
10827552
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [534774]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

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