Drug General Information
Drug ID	D0B0IJ
Former ID	DNC001177
Drug Name	Pyrrolidine dithiocarbamate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535291], [535472]
Structure		Download 2D MOL 3D MOL
Formula	C5H9NS2
Canonical SMILES	C1CCN(C1)C(=S)S
InChI	1S/C5H9NS2/c7-5(8)6-3-1-2-4-6/h1-4H2,(H,7,8)
InChIKey	VSWDORGPIHIGNW-UHFFFAOYSA-N
CAS Number	CAS 59865-13-3
PubChem Compound ID	65351
PubChem Substance ID	604743, 3727018, 7642561, 8189641, 11447547, 15297429, 35967766, 43122158, 47217241, 47662745, 47662746, 47736969, 48035608, 50064626, 53788062, 57315450, 78955395, 85147455, 92151716, 93237934, 103558396, 104333532, 118053839, 125275717, 125326196, 126423383, 129522173, 130932762, 132003405, 134339326, 134340403, 135022774, 135062358, 137255384, 137255386, 142353673, 162223499, 162497954, 164847272, 167771327, 179331533, 223444048, 226659791, 249940866
ChEBI ID	ChEBI:4031
SuperDrug ATC ID	L04AA01
SuperDrug CAS ID	cas=059865133
Target and Pathway
Target(s)	Nuclear factor NF-kappa-B	Target Info	Inhibitor	[535291], [535472]
KEGG Pathway	MAPK signaling pathway
	NF-kappa B signaling pathway
	Osteoclast differentiation
	Legionellosis
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
NetPath Pathway	IL5 Signaling Pathway
PANTHER Pathway	Apoptosis signaling pathway
	B cell activation
	Inflammation mediated by chemokine and cytokine signaling pathway
	T cell activation
	Toll receptor signaling pathway
Pathway Interaction Database	IL12-mediated signaling events
	Alternative NF-kappaB pathway
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	RIP-mediated NFkB activation via ZBP1
	DEx/H-box helicases activate type I IFN and inflammatory cytokines production
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	Interleukin-1 processing
	IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
	IkBA variant leads to EDA-ID
	Dectin-1 mediated noncanonical NF-kB signaling
	NIK-->noncanonical NF-kB signaling
	TRAF6 mediated NF-kB activation
WikiPathways	Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	SIDS Susceptibility Pathways
	Nuclear Receptors Meta-Pathway
	Cytosolic sensors of pathogen-associated DNA
	TAK1 activates NFkB by phosphorylation and activation of IKKs complex
	EBV LMP1 signaling
	TNF alpha Signaling Pathway
	TSLP Signaling Pathway
	Neural Crest Differentiation
	TWEAK Signaling Pathway
	RANKL/RANK Signaling Pathway
	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
	Interleukin-1 processing
	Folate Metabolism
	Vitamin B12 Metabolism
	Selenium Micronutrient Network
	Regulation of toll-like receptor signaling pathway
References
Ref 535291	Role of nuclear factor-kappaB in a rat model of vascular injury. Naunyn Schmiedebergs Arch Pharmacol. 2001 Oct;364(4):343-50.
Ref 535472	Simulated ischemia induces renal tubular cell apoptosis through a nuclear factor-kappaB dependent mechanism. J Urol. 2002 Jul;168(1):248-52.
Ref 535291	Role of nuclear factor-kappaB in a rat model of vascular injury. Naunyn Schmiedebergs Arch Pharmacol. 2001 Oct;364(4):343-50.
Ref 535472	Simulated ischemia induces renal tubular cell apoptosis through a nuclear factor-kappaB dependent mechanism. J Urol. 2002 Jul;168(1):248-52.

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