Drug General Information
Drug ID
D0W3NA
Former ID
DNC003037
Drug Name
Coenzyme A
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540045]
Structure
Download
2D MOL

3D MOL

Formula
C21H36N7O16P3S
InChI
InChI=1S/C21H36N7O16P3S/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35)/t11-,14-,15-,16+,20-/m1/s1
InChIKey
RGJOEKWQDUBAIZ-IBOSZNHHSA-N
CAS Number
CAS 85-61-0
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Pantothenate kinase Target Info Inhibitor [551393]
3-hydroxy-3-methylglutaryl-coenzyme A reductase Target Info Inhibitor [551393]
Probable naphthoate synthase menB Target Info Inhibitor [551393]
Phosphopantetheine adenylyltransferase Target Info Inhibitor [551393]
Carnitine acyltransferase Target Info Inhibitor [551393]
BioCyc Pathway Superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
Superpathway of cholesterol biosynthesis
Mevalonate pathway
KEGG Pathway Terpenoid backbone biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
AMPK signaling pathway
Bile secretionhsa00770:Pantothenate and CoA biosynthesis
NetPath Pathway IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
PANTHER Pathway Cholesterol biosynthesis
PathWhiz Pathway Steroid Biosynthesis
WikiPathways Statin Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Activation of Gene Expression by SREBP (SREBF)
SREBF and miR33 in cholesterol and lipid homeostasis
Integrated Breast Cancer Pathway
SREBP signalling
Cholesterol BiosynthesisWP1857:Metabolism of water-soluble vitamins and cofactors
References
Ref 540045(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3044).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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