Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D00MCG
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| Former ID |
DNC007246
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| Drug Name |
2-(1H-indol-5-yl)-6-morpholino-4H-pyran-4-one
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [528738] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C17H16N2O3
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| Canonical SMILES |
C1COCCN1C2=CC(=O)C=C(O2)C3=CC4=C(C=C3)NC=C4
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| InChI |
1S/C17H16N2O3/c20-14-10-16(13-1-2-15-12(9-13)3-4-18-15)22-17(11-14)19-5-7-21-8-6-19/h1-4,9-11,18H,5-8H2
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| InChIKey |
AWODDYAKSFDGCI-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | DNA-dependent protein kinase catalytic subunit | Target Info | Inhibitor | [528738] | |
| KEGG Pathway | Non-homologous end-joining | ||||
| Cell cycle | |||||
| NetPath Pathway | IL1 Signaling Pathway | ||||
| Reactome | Nonhomologous End-Joining (NHEJ) | ||||
| References | |||||
| Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. | ||||
| Ref 528738 | J Med Chem. 2007 Apr 19;50(8):1958-72. Epub 2007 Mar 20.Pyranone, thiopyranone, and pyridone inhibitors of phosphatidylinositol 3-kinase related kinases. Structure-activity relationships for DNA-dependent protein kinase inhibition, and identification of the first potent and selective inhibitor of the ataxia telangiectasia mutated kinase. | ||||
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