TTD | Drug: D09NBN

Drug General Information
Drug ID	D09NBN
Former ID	DNC004425
Drug Name	PD-161182
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541095]
Structure		Download 2D MOL 3D MOL
Formula	C29H40F2N4O4
InChI	InChI=1S/C29H40F2N4O4/c1-20(2)25(21-13-8-7-9-14-21)39-28(38)35-29(3,19-22-15-12-16-23(30)24(22)31)26(36)33-17-10-5-4-6-11-18-34-27(32)37/h7-9,12-16,20,25H,4-6,10-11,17-19H2,1-3H3,(H,33,36)(H,35,38)(H3,32,34,37)/t25-,29-/m0/s1
InChIKey	IWEYVTFOHKCWJN-SVEHJYQDSA-N
PubChem Compound ID	10745164
PubChem Substance ID	15781483, 23019814, 76056670, 103226412, 103947791, 178102392
Target and Pathway
Target(s)	Nigral tachykinin NK(3) receptor	Target Info	Inhibitor	[551281]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541095	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5767).
Ref 551281	The development of a novel series of non-peptide tachykinin NK3 receptor selective antagonists, Bioorg. Med. Chem. Lett. 5(16):1773-1778 (1995).

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Drug Information