Drug Information

Drug General Information
Drug ID
D0B2WX
Former ID
DNC011627
Drug Name
2-(4-Methoxy-phenyl)-8-methyl-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534774]
Structure
Download
2D MOL

3D MOL
Formula
C16H14N2O2
Canonical SMILES
CC1=CC=CC2=C1NC(=NC2=O)C3=CC=C(C=C3)OC
InChI
1S/C16H14N2O2/c1-10-4-3-5-13-14(10)17-15(18-16(13)19)11-6-8-12(20-2)9-7-11/h3-9H,1-2H3,(H,17,18,19)
InChIKey
HTLUBFSSIMOABR-UHFFFAOYSA-N
PubChem Compound ID
10730460
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [534774]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).
Ref 534774J Med Chem. 1998 Dec 17;41(26):5247-56.Resistance-modifying agents. 5. Synthesis and biological properties of quinazolinone inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase (PARP).

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.