Drug Information

Drug General Information
Drug ID
D0R2KY
Former ID
DAP000856
Drug Name
Ethynodiol Diacetate
Synonyms
Cervicundin; Continuin; Femulen; Luteonorm; Metrodiol; Ethinodiol diacetate; Ethyndiol Diacetate; Ethynodiol diacetate [Progestins]; Ethynodiol diacetate [USAN]; Etynodiol Acetate; Metrodiol diacetate; Ovulen 50; SC 11800; Etynodiol di(acetate); Luto-metrodiol; SC-11800; Ethynodiol diacetate (JAN/USP);[(3S,8R,9S,10R,13S,14S,17R)-17-acetyloxy-17-ethynyl-13-methyl-2,3,6,7,8,9,10,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate; (3 beta, 17 alpha)-19-Norpregn-4-en-20-yne-3,17 diolDiacetate; (3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol diacetate; (3beta,17beta)-17-ethynylestr-4-ene-3,17-diyl diacetate; 17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol diacetate; 17-alpha-Ethynyl-3,17-dihydroxy-4-estrene diacetate; 17-alpha-Ethynyl-4-estrene-3-beta,17-beta-diol diacetate; 17-alpha-Ethynylestr-4-ene-3-beta,17-beta-diol acetate; 17alpha-Ethynyl-19-norandrost-4-ene-3beta,17-beta-diol diacetate; 17alpha-Ethynyl-3,17-dihydroxy-4-estrene diacetate; 17alpha-Ethynyl-4-estrene-3beta,17beta-diol diacetate; 17alpha-Ethynylestr-4-ene-3beta,17beta-diol acetate; 17alpha-ethynylestr-4-ene-3beta,17beta-diyl diacetate; 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol diacetate; 19-Nor-17-alpha-pregn-4-en-20-yne-3-beta,17-diol, diacetate; 19-Nor-17alpha-pregn-4-en-20-yne-3beta,17-diol diacetate; 3-beta, 17-beta-Diacetoxy-17-alpha-ethynyl-4-oestrene; 3-beta,17-beta-Diacetoxy-19-nor-17-alpha-pregn-4-en-20-yne; 3beta, 17beta-Diacetoxy-17alpha-ethynyl-4-oestrene; 3beta,17beta-Diacetoxy-17alpha-ethynyl-4-estrene; 3beta,17beta-Diacetoxy-19-nor-17alpha-pregn-4-en-20-yne
Drug Type
Small molecular drug
Indication Hormonal contraceptives [ICD10:Z30] Approved [538500], [542078]
Therapeutic Class
Contraceptive Agents
Structure
Download
2D MOL

3D MOL
Formula
C24H32O4
InChI
InChI=1S/C24H32O4/c1-5-24(28-16(3)26)13-11-22-21-8-6-17-14-18(27-15(2)25)7-9-19(17)20(21)10-12-23(22,24)4/h1,14,18-22H,6-13H2,2-4H3/t18-,19-,20+,21+,22-,23-,24-/m0/s1
InChIKey
ONKUMRGIYFNPJW-KIEAKMPYSA-N
CAS Number
CAS 297-76-7
PubChem Compound ID
9270
PubChem Substance ID
583113, 7848357, 8139904, 8156628, 11466936, 11468056, 11486691, 14902678, 24702336, 24894643, 29217896, 29227881, 46506993, 47500789, 47870982, 48095779, 48319751, 48413769, 48414261, 48415985, 49699205, 49857373, 50111736, 50648543, 56352901, 57325544, 71822885, 92125722, 103770607, 103914593, 104320059, 121363393, 126688192, 128834236, 131309376, 134224557, 134338135, 134974637, 137009574, 140504082, 144205886, 144206477, 152034671, 160964165, 162177765, 163692857, 164815702, 170464933, 172867017, 175267492
ChEBI ID
ChEBI:31580
SuperDrug ATC ID
G03DC06
Target and Pathway
Target(s) Progesterone receptor Target Info Binder [537774], [537954]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 538500FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 018168.
Ref 542078(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7072).
Ref 537774The place of progestational hormones in gynecological therapy. Ginekol Pol. 1970 May;41(5):497-502.
Ref 537954Contribution of functional groups of 19-nor-progestogens to binding to progesterone and estradiol-17beta receptors in rabbit uterus. Endocrinology. 1977 Jun;100(6):1579-84.

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