Drug Information

Drug General Information
Drug ID
D0EM1C
Former ID
DIB019124
Drug Name
Chk2 inhibitor II
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541235]
Structure
Download
2D MOL
Formula
C20H14ClN3O2
InChI
InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
InChIKey
UXGJAOIJSROTTN-UHFFFAOYSA-N
PubChem Compound ID
9969021
PubChem Substance ID
14946094, 24724438, 26758462, 29217525, 46065591, 53800940, 75566488, 85301072, 91146360, 99302680, 103439921, 104219750, 139865336, 139865341, 144221240, 162248071, 163123195, 163688374, 170484625, 175607470, 178102577, 179694520, 204378863, 208265147, 210275017, 210280655, 223704974, 227904993, 243086193, 246265614, 252215134, 252477940
Target and Pathway
Target(s) Serine/threonine-protein kinase Chk2 Target Info Inhibitor [529213]
KEGG Pathway Cell cycle
p53 signaling pathway
HTLV-I infection
Pathway Interaction Database ATM pathway
FOXM1 transcription factor network
p53 pathway
PLK3 signaling events
Reactome Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
WikiPathways DNA Damage Response
ATM Signaling Pathway
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 541235(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5954).
Ref 529213Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. Epub 2007 Dec 11.A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.

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