Drug General Information
Drug ID	D0E0EQ
Former ID	DNC007638
Drug Name	2-methylbut-3-yn-2-yl 4-methoxybenzoate
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529037]
Structure		Download 2D MOL 3D MOL
Formula	C13H14O3
Canonical SMILES	CC(C)(C#C)OC(=O)C1=CC=C(C=C1)OC
InChI	1S/C13H14O3/c1-5-13(2,3)16-12(14)10-6-8-11(15-4)9-7-10/h1,6-9H,2-4H3
InChIKey	WRGOVRZCLGHFFF-UHFFFAOYSA-N
PubChem Compound ID	708205
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Inhibitor	[529037]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.
Ref 529037	J Med Chem. 2007 Oct 4;50(20):4928-38. Epub 2007 Sep 12.N-benzoylpyrazoles are novel small-molecule inhibitors of human neutrophil elastase.

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