Drug General Information
Drug ID	D04PDF
Former ID	DNC007055
Drug Name	Cyclo(-D-Tyr-L-Arg-L-Arg-L-Nal-L-Ala-)
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528618]
Structure		Download 2D MOL 3D MOL
Formula	C37H49N11O6
PubChem Compound ID	44418872
Target and Pathway
Target(s)	C-X-C chemokine receptor 4	Target Info	Inhibitor	[528618]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Endocytosis
	Axon guidance
	Leukocyte transendothelial migration
	Intestinal immune network for IgA production
	Pathways in cancer
NetPath Pathway	IL2 Signaling Pathway
	IL4 Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	Axon guidance mediated by Slit/Robo
	Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database	S1P3 pathway
	CXCR4-mediated signaling events
	Syndecan-4-mediated signaling events
	HIF-1-alpha transcription factor network
	Ephrin B reverse signaling
Reactome	Binding and entry of HIV virion
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Hematopoietic Stem Cell Differentiation
	HIV Life Cycle
	Cardiac Progenitor Differentiation
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 528618	J Med Chem. 2007 Jan 25;50(2):192-8.Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.
Ref 528618	J Med Chem. 2007 Jan 25;50(2):192-8.Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.

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