Drug Information

Drug General Information
Drug ID
D01JWT
Former ID
DNC012220
Drug Name
2-(10-Imidazol-1-yl-decyl)-isoindole-1,3-dione
Drug Type
Small molecular drug
Indication Discovery agent Investigative [533459]
Structure
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2D MOL

3D MOL
Formula
C21H27N3O2
Canonical SMILES
C1=CC=C2C(=C1)C(=O)N(C2=O)CCCCCCCCCCN3C=CN=C3
InChI
1S/C21H27N3O2/c25-20-18-11-7-8-12-19(18)21(26)24(20)15-10-6-4-2-1-3-5-9-14-23-16-13-22-17-23/h7-8,11-13,16-17H,1-6,9-10,14-15H2
InChIKey
DOVKNTJKHQSOTE-UHFFFAOYSA-N
PubChem Compound ID
13588977
Target and Pathway
Target(s) Thromboxane-A synthase Target Info Inhibitor [533459]
BioCyc Pathway C20 prostanoid biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathways
Platelet activation
PathWhiz Pathway Arachidonic Acid Metabolism
WikiPathways Prostaglandin Synthesis and Regulation
Arachidonic acid metabolism
Phase 1 - Functionalization of compounds
Eicosanoid Synthesis
References
Ref 533459J Med Chem. 1986 May;29(5):816-9.Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.
Ref 533459J Med Chem. 1986 May;29(5):816-9.Thromboxane synthetase inhibitors and antihypertensive agents. 2. N-[(1H-imidazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones and N-[(1H-1,2,4-triazol-1-yl)alkyl]-1H-isoindole-1,3(2H)-diones as unique antihypertensive agents.

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