Drug Information
Drug General Information | |||||
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Drug ID |
D06DKB
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Former ID |
DNC011027
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Drug Name |
GNF-PF-4478
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [531262] | ||
Structure |
Download2D MOL |
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Formula |
C17H20ClN5O
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Canonical SMILES |
C1COCCN1CCCNC2=NC=NC3=C2NC4=C3C=C(C=C4)Cl
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InChI |
1S/C17H20ClN5O/c18-12-2-3-14-13(10-12)15-16(22-14)17(21-11-20-15)19-4-1-5-23-6-8-24-9-7-23/h2-3,10-11,22H,1,4-9H2,(H,19,20,21)
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InChIKey |
ULJISGNQAXNPOC-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Insulin-degrading Enzyme | Target Info | Inhibitor | [531262] | |
Cruzipain | Target Info | Inhibitor | [530968] | ||
KEGG Pathway | Alzheimer's disease | ||||
WikiPathways | Alzheimers Disease | ||||
References | |||||
Ref 530968 | J Med Chem. 2010 Jul 8;53(13):4891-905.Complementarity between a docking and a high-throughput screen in discovering new cruzain inhibitors. | ||||
Ref 531262 | Bioorg Med Chem Lett. 2010 Dec 15;20(24):7331-6. Epub 2010 Oct 21.In silico identification and biochemical evaluation of novel inhibitors of NRH:quinone oxidoreductase 2 (NQO2). |
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