Drug Information

Drug General Information
Drug ID
D02YIJ
Former ID
DIB020083
Drug Name
isocarbacyclin
Synonyms
9-O-methanoprostaglandin I
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539234]
Structure
Download
2D MOL
Formula
C21H34O4
InChI
InChI=1S/C21H34O4/c1-2-3-4-8-17(22)10-11-18-19-13-15(7-5-6-9-21(24)25)12-16(19)14-20(18)23/h10-12,16-20,22-23H,2-9,13-14H2,1H3,(H,24,25)/b11-10+/t16-,17-,18+,19-,20+/m0/s1
InChIKey
JANVYOZZTKSZGN-WCAFQOMDSA-N
PubChem Compound ID
5311244
PubChem Substance ID
7979797, 11056375, 14802895, 16220523, 39340952, 50164485, 114155655, 135650430, 198939361, 240624133, 241152515
Target and Pathway
Target(s) Prostacyclin receptor Target Info Agonist [534478]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [534478]
Prostaglandin E2receptor, EP2 subtype Target Info Agonist [534478]
KEGG Pathway Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Platelet activationhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Pathways in cancerhsa04024:cAMP signaling pathway
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin
Reactome Prostanoid ligand receptors
G alpha (s) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Small Ligand GPCRs
Endothelin Pathways
Platelet homeostasis
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
Ovarian Infertility Genes
GPCR downstream signaling
References
Ref 539234(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1934).
Ref 534478Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol. 1997 Sep;122(2):217-24.

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