Drug Information

Drug General Information
Drug ID
D00FMX
Former ID
DNC010335
Drug Name
3-(piperidin-4-yl)-2-(o-tolyloxy)pyridine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530596]
Structure
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2D MOL

3D MOL
Formula
C17H20N2O
Canonical SMILES
CC1=CC=CC=C1OC2=C(C=CC=N2)C3CCNCC3
InChI
1S/C17H20N2O/c1-13-5-2-3-7-16(13)20-17-15(6-4-10-19-17)14-8-11-18-12-9-14/h2-7,10,14,18H,8-9,11-12H2,1H3
InChIKey
BLKKGRNFYMEBJN-UHFFFAOYSA-N
PubChem Compound ID
46230706
Target and Pathway
Target(s) Sodium-dependent noradrenaline transporter Target Info Inhibitor [530596]
5-hydroxytryptamine 1A receptor Target Info Inhibitor [530596]
Sodium-dependent serotonin transporter Target Info Inhibitor [530596]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04726:Serotonergic synapse
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Adrenaline and noradrenaline biosynthesisP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP04373:5HT1 type receptor mediated signaling pathway
5HT2 type receptor mediated signaling pathway
5HT3 type receptor mediated signaling pathway
5HT4 type receptor mediated signaling pathway
Reactome Na+/Cl- dependent neurotransmitter transportersR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Monoamine Transport
NRF2 pathway
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsWP722:Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP727:Monoamine Transport
Synaptic Vesicle Pathway
Serotonin Transporter Activity
References
Ref 530596Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.
Ref 530596Bioorg Med Chem Lett. 2010 Feb 1;20(3):1114-7. Epub 2009 Dec 6.Design, synthesis, and pharmacological evaluation of phenoxy pyridyl derivatives as dual norepinephrine reuptake inhibitors and 5-HT1A partial agonists.

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