Drug General Information
Drug ID	D0R4BS
Former ID	DNC005413
Drug Name	N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide
Synonyms	N-hydroxy-4-(3-phenylpropanamido)benzamide
Indication	Discovery agent		Investigative	[527691]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Histone deacetylase 2	Target Info	Inhibitor	[530261]
	Histone Deacetylase 10	Target Info	Inhibitor	[527691]
	Histone Deacetylase 8	Target Info	Inhibitor	[527691]
	Histone deacetylase 1	Target Info	Inhibitor	[530261]
	Histone deacetylase 6	Target Info	Inhibitor	[527691]
	Histone deacetylase 4	Target Info	Inhibitor	[527691]
	Histone deacetylase	Target Info	Inhibitor	[527691]
KEGG Pathway	Cell cycle
	Notch signaling pathway
	Thyroid hormone signaling pathway
	Huntington's disease
	Alcoholism
	Epstein-Barr virus infection
	Pathways in cancer
	Transcriptional misregulation in cancer
	Viral carcinogenesis
	Chronic myeloid leukemiahsa05034:Alcoholism
	Viral carcinogenesishsa04110:Cell cycle
	Amphetamine addiction
	MicroRNAs in cancer
	Viral carcinogenesishsa05034:Alcoholism
NetPath Pathway	TCR Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
PANTHER Pathway	Wnt signaling pathwayP00057:Wnt signaling pathwayP00057:Wnt signaling pathway
	p53 pathway
Pathway Interaction Database	Regulation of nuclear SMAD2/3 signaling
	Signaling events mediated by HDAC Class I
	Regulation of Telomerase
	Glucocorticoid receptor regulatory network
	Direct p53 effectors
	Hedgehog signaling events mediated by Gli proteins
	Regulation of nuclear beta catenin signaling and target gene transcriptionhdac_classii_pathway:Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class Ihdac_classi_pathway:Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
	Notch signaling pathway
	E2F transcription factor network
	Presenilin action in Notch and Wnt signaling
	Sumoylation by RanBP2 regulates transcriptional repression
	Regulation of Androgen receptor activity
	IL3-mediated signaling events
	Validated nuclear estrogen receptor alpha network
	Retinoic acid receptors-mediated signaling
	Regulation of nuclear beta catenin signaling and target gene transcription
	Validated targets of C-MYC transcriptional repression
	Regulation of retinoblastoma protein
	Notch-mediated HES/HEY networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
	Signaling events mediated by HDAC Class III
Reactome	p75NTR negatively regulates cell cycle via SC1
	NOTCH1 Intracellular Domain Regulates Transcription
	Constitutive Signaling by NOTCH1 PEST Domain Mutants
	Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
	HDACs deacetylate histones
	NoRC negatively regulates rRNA expression
	RNA Polymerase I Transcription Initiation
	Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
	HDACs deacetylate histonesR-HSA-1538133:G0 and Early G1
	Formation of the beta-catenin:TCF transactivating complex
	SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
	Deactivation of the beta-catenin transactivating complex
	Assembly of the primary ciliumR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
WikiPathways	Notch Signaling Pathway
	Notch Signaling Pathway
	Neural Crest Differentiation
	Signalling by NGF
	RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
	Factors involved in megakaryocyte development and platelet production
	Cell CycleWP2377:Integrated Pancreatic Cancer Pathway
	Cell CycleWP706:SIDS Susceptibility Pathways
	TGF beta Signaling Pathway
	IL-6 signaling pathway
	Apoptosis-related network due to altered Notch3 in ovarian cancer
	Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
	Retinoblastoma (RB) in Cancer
	TWEAK Signaling Pathway
	Integrated Breast Cancer Pathway
	Mitotic G1-G1/S phases
	Cell Cycle
	Androgen receptor signaling pathwayWP2858:Ectoderm Differentiation
	Cell CycleWP474:Endochondral Ossification
	Cardiac Hypertrophic Response
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	TarBasePathway
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 527691	J Med Chem. 2005 Aug 25;48(17):5530-5.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.
Ref 527691	J Med Chem. 2005 Aug 25;48(17):5530-5.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.
Ref 530261	Eur J Med Chem. 2009 Nov;44(11):4470-6. Epub 2009 Jun 17.Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors.

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