Drug Information

Drug General Information
Drug ID
D0L4RX
Former ID
DNC012880
Drug Name
PB-81
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527568]
Structure
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2D MOL

3D MOL
Formula
C26H31N7O3S
Canonical SMILES
CC(C)(C)NC(=O)CN(C1CC2=C(C=CC(=C2)C#N)N(C1)CC3=CN=CN3C)<br />S(=O)(=O)C4=CC=NC=C4
InChI
1S/C26H31N7O3S/c1-26(2,3)30-25(34)17-33(37(35,36)23-7-9-28-10-8-23)21-12-20-11-19(13-27)5-6-24(20)32(15-21)16-22-14-29-18-31(22)4/h5-11,14,18,21H,12,15-17H2,1-4H3,(H,30,34)
InChIKey
VXYRLLDULVRHBY-UHFFFAOYSA-N
PubChem Compound ID
11214581
Target and Pathway
Target(s) Farnesyltransferase Target Info Inhibitor [527568]
Protein farnesyltransferase beta subunit Target Info Inhibitor [527568]
KEGG Pathway Terpenoid backbone biosynthesis
Biosynthesis of antibioticshsa00900:Terpenoid backbone biosynthesis
Biosynthesis of antibiotics
NetPath Pathway TSH Signaling Pathway
Reactome Apoptotic cleavage of cellular proteins
Inactivation, recovery and regulation of the phototransduction cascadeR-HSA-2514859:Inactivation, recovery and regulation of the phototransduction cascade
WikiPathways Visual phototransduction
Apoptotic execution phaseWP2776:Visual phototransduction
References
Ref 527568J Med Chem. 2005 Jun 2;48(11):3704-13.Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.
Ref 527568J Med Chem. 2005 Jun 2;48(11):3704-13.Protein farnesyltransferase inhibitors exhibit potent antimalarial activity.

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