Drug Information

Drug General Information
Drug ID
D06VBQ
Former ID
DNC010550
Drug Name
GSK-0660
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540381]
Structure
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2D MOL

3D MOL
Formula
C19H18N2O5S2
InChI
InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
InChIKey
NDFKBGWLUHKMFY-UHFFFAOYSA-N
PubChem Compound ID
46233311
PubChem Substance ID
92098465, 103729483, 120487529, 125692010, 134347755, 135698885, 160862456, 162248483, 162768135, 164042011, 172087002, 177748979, 178100441, 185998156, 204371608, 223389077, 239934889, 241376459, 244111304, 249617877, 252157288, 252450401, 252553665
Target and Pathway
Target(s) Peroxisomeproliferator activated receptor delta Target Info Inhibitor [530686]
KEGG Pathway PPAR signaling pathway
Wnt signaling pathway
Pathways in cancer
Acute myeloid leukemia
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway Wnt signaling pathway
Pathway Interaction Database Presenilin action in Notch and Wnt signaling
RXR and RAR heterodimerization with other nuclear receptor
Reactome Import of palmitoyl-CoA into the mitochondrial matrix
Regulation of pyruvate dehydrogenase (PDH) complex
Nuclear Receptor transcription pathway
WikiPathways Wnt Signaling Pathway and Pluripotency
Nuclear Receptors in Lipid Metabolism and Toxicity
NRF2 pathway
Nuclear Receptors Meta-Pathway
Vitamin D Receptor Pathway
Ectoderm Differentiation
Adipogenesis
Nuclear Receptors
References
Ref 540381(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3441).
Ref 530686J Med Chem. 2010 Feb 25;53(4):1857-61.Identification and characterization of 4-chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist.

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