Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0I2FI
|
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| Former ID |
DIB018049
|
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| Drug Name |
dequalinium
|
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| Drug Type |
Small molecular drug
|
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| Indication | Myeloneuropathy [ICD10:G04.1] | Clinical trial | [526067] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C30H40N4+2
|
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| InChI |
InChI=1S/C30H38N4/c1-23-21-27(31)25-15-9-11-17-29(25)33(23)19-13-7-5-3-4-6-8-14-20-34-24(2)22-28(32)26-16-10-12-18-30(26)34/h9-12,15-18,21-22,31-32H,3-8,13-14,19-20H2,1-2H3/p+2
|
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| InChIKey |
PCSWXVJAIHCTMO-UHFFFAOYSA-P
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
794674, 823756, 5321553, 5321554, 7886971, 7980363, 8151905, 11111064, 11111065, 11113637, 11335927, 11361166, 11363045, 11365607, 11368169, 11374253, 11376331, 11405693, 11447327, 11462138, 11466416, 11467536, 11484395, 11486232, 11488466, 11492572, 11493965, 24262993, 29222142, 46507206, 47216801, 47216802, 47216803, 47365217, 47365218, 47810773, 47959772, 48185024, 48498627, 49698466, 50065046, 50104538, 50126458, 50126464, 56435827, 56435829, 57321546, 68533857, 76767627, 90340946
|
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| Target and Pathway | |||||
| Target(s) | CNGA2 | Target Info | Blocker (channel blocker) | [526973] | |
| CNGA1 | Target Info | Blocker (channel blocker) | [526498] | ||
| KCa2.1 | Target Info | Blocker (channel blocker) | [525707] | ||
| KCa2.3 | Target Info | Blocker (channel blocker) | [526067] | ||
| KCa2.2 | Target Info | Blocker (channel blocker) | [525837] | ||
| References | |||||
| Ref 525707 | Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. | ||||
| Ref 525837 | Block of rat brain recombinant SK channels by tricyclic antidepressants and related compounds. Eur J Pharmacol. 2000 Jul 28;401(1):1-7. | ||||
| Ref 526067 | Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83. | ||||
| Ref 526498 | Dequalinium: a novel, high-affinity blocker of CNGA1 channels. J Gen Physiol. 2003 Jan;121(1):37-47. | ||||
| Ref 526973 | State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304. | ||||
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