Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04LOE
|
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| Former ID |
DIB019386
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| Drug Name |
compound 26
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| Synonyms |
1,2,4-oxadiazole_based compound 26; Merck SIP agonist
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| Drug Type |
Small molecular drug
|
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| Formula |
C23H25N3O3
|
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| InChI |
InChI=1S/C23H25N3O3/c1-15(2)11-16-3-9-19(10-4-16)22-24-21(25-29-22)18-7-5-17(6-8-18)12-26-13-20(14-26)23(27)28/h3-10,15,20H,11-14H2,1-2H3,(H,27,28)
|
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| InChIKey |
SHQNRSGKLNMHOS-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [527767] | |
| S1P4 receptor | Target Info | Agonist | [527767] | ||
| Sphingosine-1-phosphate receptor-3 | Target Info | Agonist | [527767] | ||
| Sphingosine 1-phosphate receptor 5 | Target Info | Agonist | [527767] | ||
| References | |||||
| Ref 527767 | Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73. | ||||
| Ref 539946 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2929). | ||||
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