Drug Information

Drug General Information
Drug ID
D0O3FC
Former ID
DNC010859
Drug Name
AMG-5445
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551343]
Structure
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2D MOL

3D MOL
Formula
C16H13Cl4NO2S
Canonical SMILES
COC1=CC=C(C=C1)C(=O)NC(C(Cl)(Cl)Cl)SC2=CC=C(C=C2)Cl
InChI
1S/C16H13Cl4NO2S/c1-23-12-6-2-10(3-7-12)14(22)21-15(16(18,19)20)24-13-8-4-11(17)5-9-13/h2-9,15H,1H3,(H,21,22)
InChIKey
MRIRDTYIRGDISF-UHFFFAOYSA-N
PubChem Compound ID
2830270
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Inhibitor [551343]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 551343Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. doi: 10.1021/jm100062h.
Ref 551343Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents. J Med Chem. 2010 Jul 22;53(14):5085-107. doi: 10.1021/jm100062h.

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