Drug General Information
Drug ID	D06KTD
Former ID	DNC004671
Drug Name	2-Hydrazinocarbonyl-benzenesulfonamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527482]
Structure		Download 2D MOL 3D MOL
Formula	C7H9N3O3S
Canonical SMILES	C1=CC=C(C(=C1)C(=O)NN)S(=O)(=O)N
InChI	1S/C7H9N3O3S/c8-10-7(11)5-3-1-2-4-6(5)14(9,12)13/h1-4H,8H2,(H,10,11)(H2,9,12,13)
InChIKey	YWPOXIABDFDDSR-UHFFFAOYSA-N
PubChem Compound ID	2490720
Target and Pathway
Target(s)	Carbonic anhydrase II	Target Info	Inhibitor	[527482]
	Carbonic anhydrase IX	Target Info	Inhibitor	[527482]
KEGG Pathway	Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretionhsa00910:Nitrogen metabolism
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Pathway Interaction Database	HIF-1-alpha transcription factor network
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxideR-HSA-1234158:Regulation of gene expression by Hypoxia-inducible Factor
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by ErythrocytesWP2877:Vitamin D Receptor Pathway
	Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
References
Ref 527482	J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties.
Ref 527482	J Med Chem. 2005 Mar 24;48(6):2121-5.Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/membrane-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporatinghydrazino moieties.

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