Drug Information

Drug General Information
Drug ID
D0U5WY
Former ID
DNC005174
Drug Name
2-(3-Piperidin-1-yl-propyl)-3H-quinazolin-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527159]
Structure
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2D MOL

3D MOL
Formula
C16H21N3O
Canonical SMILES
C1CCN(CC1)CCCC2=NC(=O)C3=CC=CC=C3N2
InChI
1S/C16H21N3O/c20-16-13-7-2-3-8-14(13)17-15(18-16)9-6-12-19-10-4-1-5-11-19/h2-3,7-8H,1,4-6,9-12H2,(H,17,18,20)
InChIKey
HDVNQQSSIKDDKS-UHFFFAOYSA-N
PubChem Compound ID
11311783
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [527159]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527159J Med Chem. 2004 Aug 12;47(17):4151-4.Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.
Ref 527159J Med Chem. 2004 Aug 12;47(17):4151-4.Rational approaches to discovery of orally active and brain-penetrable quinazolinone inhibitors of poly(ADP-ribose)polymerase.

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