Drug Information

Drug General Information
Drug ID
D0S5CU
Former ID
DAP000595
Drug Name
Nisoldipine
Synonyms
Baymycard; Nisocor; Nisoldipin; Nisoldipino; Nisoldipinum; Sular; Syscor; Zadipina; Bay k 5552; Nisoldipino [INN-Spanish]; Nisoldipinum [INN-Latin]; Sular (TN); Bay-k-5552; Nisoldipine (JAN/USAN/INN); Nisoldipine [USAN:BAN:INN:JAN]; Isobutyl 1,4-dihydro-5-methoxycarbonyl-2,6-dimethyl-4-(2-nitrophenyl)-3-pyridincarboxylat;Methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; (+-)-Isobutyl methyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate; 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, methyl 2-methylpropyl ester; 3-O-methyl 5-O-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Drug Type
Small molecular drug
Indication Hypertension [ICD9: 401; ICD10:I10-I16] Approved [538334], [539644]
Therapeutic Class
Antihypertensive Agents
Structure
Download
2D MOL

3D MOL
Formula
C20H24N2O6
InChI
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChIKey
VKQFCGNPDRICFG-UHFFFAOYSA-N
CAS Number
CAS 63675-72-9
PubChem Compound ID
4499
PubChem Substance ID
9901, 5054384, 6595685, 6951250, 7594280, 7847684, 7980129, 8152772, 11528722, 12012773, 14780577, 26719878, 26758055, 29223593, 46386699, 46504546, 48416330, 49681768, 53787999, 56313694, 56463094, 57322301, 80626920, 81092916, 92307945, 92308528, 92308896, 92711446, 93166842, 103219831, 103680984, 104306583, 117875317, 118048486, 121363368, 124658895, 124799896, 125355226, 126630843, 126657331, 126665640, 131322121, 131846259, 134337886, 135004762, 135650722, 135692260, 137122027, 137349418, 139157574
SuperDrug ATC ID
C08CA07
SuperDrug CAS ID
cas=063675729
Target and Pathway
Target(s) Calcium channel Target Info Blocker [537487]
References
Ref 538334FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 079051.
Ref 539644(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2524).
Ref 537487RT-PCR and pharmacological analysis of L-and T-type calcium channels in rat carotid body. Adv Exp Med Biol. 2009;648:105-12.

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