Drug General Information
Drug ID	D0Y8CU
Former ID	DNC014778
Drug Name	5,6,8-trichloroquinoline-4-one-3-carboxylic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528489]
Structure		Download 2D MOL 3D MOL
Formula	C10H4Cl3NO3
Canonical SMILES	C1=C(C2=C(C(=C1Cl)Cl)C(=O)C(=CN2)C(=O)O)Cl
InChI	1S/C10H4Cl3NO3/c11-4-1-5(12)8-6(7(4)13)9(15)3(2-14-8)10(16)17/h1-2H,(H,14,15)(H,16,17)
InChIKey	DIMMLVONVUPWHB-UHFFFAOYSA-N
PubChem Compound ID	718154
Target and Pathway
Target(s)	Casein kinase II, alpha chain	Target Info	Inhibitor	[528489]
KEGG Pathway	Ribosome biogenesis in eukaryotes
	NF-kappa B signaling pathway
	Wnt signaling pathway
	Adherens junction
	Tight junction
	Measles
	Herpes simplex infection
	Epstein-Barr virus infection
NetPath Pathway	FSH Signaling Pathway
Pathway Interaction Database	BCR signaling pathway
	Atypical NF-kappaB pathway
	DNA-PK pathway in nonhomologous end joining
	Presenilin action in Notch and Wnt signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	E-cadherin signaling in the nascent adherens junction
	Lissencephaly gene (LIS1) in neuronal migration and development
	PDGFR-alpha signaling pathway
	Signaling mediated by p38-alpha and p38-beta
	Alpha-synuclein signaling
Reactome	Condensation of Prometaphase Chromosomes
WikiPathways	Mitotic Prometaphase
	BDNF signaling pathway
	TNF alpha Signaling Pathway
	L1CAM interactions
References
Ref 528489	J Med Chem. 2006 Nov 2;49(22):6443-50.Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2.
Ref 528489	J Med Chem. 2006 Nov 2;49(22):6443-50.Evaluation of 3-carboxy-4(1H)-quinolones as inhibitors of human protein kinase CK2.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.