Drug General Information
Drug ID	D0GI2R
Former ID	DNC010664
Drug Name	N-[(5-chloro-1-benzothien-3-yl)methyl]sulfamide
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530089]
Structure		Download 2D MOL 3D MOL
Formula	C9H9ClN2O2S2
Canonical SMILES	C1=CC2=C(C=C1Cl)C(=CS2)CNS(=O)(=O)N
InChI	1S/C9H9ClN2O2S2/c10-7-1-2-9-8(3-7)6(5-15-9)4-12-16(11,13)14/h1-3,5,12H,4H2,(H2,11,13,14)
InChIKey	PURBZUVIUSNPGZ-UHFFFAOYSA-N
PubChem Compound ID	11572651
Target and Pathway
Target(s)	Carbonic anhydrase II	Target Info	Inhibitor	[530089]
KEGG Pathway	Nitrogen metabolism
	Proximal tubule bicarbonate reclamation
	Collecting duct acid secretion
	Gastric acid secretion
	Pancreatic secretion
	Bile secretion
NetPath Pathway	IL4 Signaling Pathway
	EGFR1 Signaling Pathway
Reactome	Erythrocytes take up carbon dioxide and release oxygen
	Erythrocytes take up oxygen and release carbon dioxide
	Reversible hydration of carbon dioxide
WikiPathways	Reversible Hydration of Carbon Dioxide
	Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
	Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
References
Ref 530089	J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.
Ref 530089	J Med Chem. 2009 Dec 10;52(23):7528-36.Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies.

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