Drug Information

Drug General Information
Drug ID
D0C8MT
Former ID
DNC009584
Drug Name
2-(7-(benzyloxy)-1H-indol-3-yl)ethanamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [531228]
Structure
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2D MOL

3D MOL
Formula
C17H18N2O
Canonical SMILES
C1=CC=C(C=C1)COC2=CC=CC3=C2NC=C3CCN
InChI
1S/C17H18N2O/c18-10-9-14-11-19-17-15(14)7-4-8-16(17)20-12-13-5-2-1-3-6-13/h1-8,11,19H,9-10,12,18H2
InChIKey
JOYGWYISRWPUIM-UHFFFAOYSA-N
PubChem Compound ID
260806
Target and Pathway
Target(s) Leukotriene A-4 hydrolase Target Info Inhibitor [529868]
TRPM8 protein Target Info Inhibitor [531228]
BioCyc Pathway Leukotriene biosynthesis
KEGG Pathway Arachidonic acid metabolism
Metabolic pathwayshsa04750:Inflammatory mediator regulation of TRP channels
PathWhiz Pathway Arachidonic Acid Metabolism
Reactome TRP channels
WikiPathways Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 531228Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. Epub 2010 Sep 22.5-benzyloxytryptamine as an antagonist of TRPM8.
Ref 529868J Med Chem. 2008 Dec 25;51(24):7882-8.Discovery of multitarget inhibitors by combining molecular docking with common pharmacophore matching.
Ref 531228Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. Epub 2010 Sep 22.5-benzyloxytryptamine as an antagonist of TRPM8.

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