Drug Information

Drug General Information
Drug ID
D0V9BD
Former ID
DAP000092
Drug Name
Bicalutamide
Synonyms
Casodex; Cosudex; Propanamide; Raffolutil; Astra brand of bicalutamide; AstraZeneca brand of bicalutamide; Zeneca brand of bicalutamide; Calutide (TN); Casodex (TN); Cosudex (TN); KS-1161; Kalumid (TN); Bicalutamide [USAN:INN:BAN]; Bicalutamide (JAN/USP/INN); Casodex, Cosudex, Calutide, Kalumid, Bicalutamide; N-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide; (+-)-4'-Cyano-alpha,alpha,alpha-trifluoro-3-((p-fluorophenyl)sulfonyl)-2-methyl-m-lactotoluidide; 4'-cyano-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide
Drug Type
Small molecular drug
Indication Advanced prostate cancer [ICD9: 185; ICD10:C61] Approved [536361], [539888]
Therapeutic Class
Anticancer Agents
Company
AstraZeneca plc
Structure
Download
2D MOL

3D MOL
Formula
C18H14F4N2O4S
InChI
InChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)
InChIKey
LKJPYSCBVHEWIU-UHFFFAOYSA-N
CAS Number
CAS 90357-06-5
PubChem Compound ID
2375
PubChem Substance ID
10360, 536636, 4422035, 7848024, 7978493, 8151593, 11528703, 12014029, 14807515, 26719836, 29221542, 46386630, 46505386, 46518598, 49681685, 49835627, 50113021, 50709017, 53790604, 57321290, 85174226, 85174230, 90341766, 91610973, 92308263, 92308948, 92711409, 93815120, 99016301, 99437214, 103164349, 104300407, 118046574, 121362017, 124658945, 124757067, 124800143, 124893438, 125163871, 125338410, 125359510, 125545351, 126630887, 126657361, 126665838, 128501765, 131295154, 134358448, 135014383, 135649993
ChEBI ID
ChEBI:3090
SuperDrug ATC ID
L02BB03
SuperDrug CAS ID
cas=090357065
Drug Resistance Mutation (DRM)
DRM DRM Info
Target and Pathway
Target(s) Androgen receptor Target Info Antagonist [535561], [537480]
KEGG Pathway Oocyte meiosis
Pathways in cancer
Prostate cancer
NetPath Pathway EGFR1 Signaling Pathway
AndrogenReceptor Signaling Pathway
FSH Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Nongenotropic Androgen signaling
Regulation of nuclear beta catenin signaling and target gene transcription
FOXA1 transcription factor network
Notch-mediated HES/HEY network
Reactome Nuclear Receptor transcription pathway
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways SIDS Susceptibility Pathways
Integrated Pancreatic Cancer Pathway
Prostate Cancer
Integrated Breast Cancer Pathway
Nuclear Receptors
Androgen receptor signaling pathway
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 539888(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2863).
Ref 535561Androgen receptor as a target in androgen-independent prostate cancer. Urology. 2002 Sep;60(3 Suppl 1):132-8; discussion 138-9.
Ref 537480Androgen receptor overexpression induces tamoxifen resistance in human breast cancer cells. Breast Cancer Res Treat. 2009 Jun 17.

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