Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0W2UK
|
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| Former ID |
DIB020039
|
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| Drug Name |
IK-862
|
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| Synonyms |
IK862; IK 862; compound 32
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [529692] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C25H27N3O4
|
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| InChI |
InChI=1S/C25H27N3O4/c1-16-14-18(21-6-4-5-7-22(21)26-16)15-32-20-10-8-19(9-11-20)25(3)12-13-28(24(25)30)17(2)23(29)27-31/h4-11,14,17,31H,12-13,15H2,1-3H3,(H,27,29)/t17-,25+/m1/s1
|
||||
| InChIKey |
YDMIPBHQKFOFQW-NSYGIPOTSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | ADAM 33 | Target Info | Inhibitor | [529692] | |
| ADAM 17 | Target Info | Inhibitor | [529692] | ||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| TNF receptor signaling pathway | |||||
| p75(NTR)-mediated signaling | |||||
| Reactome | Nuclear signaling by ERBB4 | ||||
| Collagen degradation | |||||
| Regulated proteolysis of p75NTR | |||||
| Activated NOTCH1 Transmits Signal to the Nucleus | |||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 t(7 | |||||
| M1580_K2555) Translocation Mutant | |||||
| Constitutive Signaling by NOTCH1 HD Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| TNF signaling | |||||
| Growth hormone receptor signaling | |||||
| References | |||||
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