Drug Information

Drug General Information
Drug ID
D0O9ES
Former ID
DIB019154
Drug Name
cloprostenol
Synonyms
ICI 80996
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539194]
Structure
Download
2D MOL
Formula
C22H29ClO6
InChI
InChI=1S/C22H29ClO6/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1
InChIKey
VJGGHXVGBSZVMZ-QIZQQNKQSA-N
PubChem Compound ID
5311053
PubChem Substance ID
7978976, 11056237, 14880541, 26754922, 26754923, 39340782, 47216548, 48110216, 50110831, 53787345, 76608563, 85787684, 92309995, 99300907, 103214324, 103985320, 114155154, 126618228, 126662417, 135260747, 135650113, 143086659, 152104394, 162175052, 162200047, 162259055, 163475429, 163640402, 175270114, 198961784, 223673329, 226494655, 241077811, 252455719, 252457292
Target and Pathway
Target(s) Prostaglandin E2 receptor, EP1 subtype Target Info Agonist [526324]
Prostaglandin F2-alpha receptor Target Info Agonist [525673]
Prostaglandin E2 receptor EP3 subtype Target Info Agonist [525673]
Thromboxane A2 receptor Target Info Agonist [525673]
Prostaglandin D2 receptor Target Info Agonist [525673]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Pathways in cancerhsa04020:Calcium signaling pathway
Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway
cAMP signaling pathway
Regulation of lipolysis in adipocytes
Platelet activationhsa04080:Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
PANTHER Pathway PI3 kinase pathway
Pathway Interaction Database Thromboxane A2 receptor signaling
PathWhiz Pathway Intracellular Signalling Through PGD2 receptor and Prostaglandin D2
Reactome Prostanoid ligand receptors
G alpha (q) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (i) signalling eventsR-HSA-391908:Prostanoid ligand receptors
G alpha (q) signalling events
G alpha (12/13) signalling events
Thromboxane signalling through TP receptorR-HSA-391908:Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signalingWP98:Prostaglandin Synthesis and Regulation
GPCR downstream signaling
GPCRs, OtherWP98:Prostaglandin Synthesis and Regulation
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Signal amplification
References
Ref 539194(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1894).
Ref 525673The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta. 2000 Jan 17;1483(2):285-93.
Ref 526324Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques. J Pharm Pharmacol. 2002 Apr;54(4):539-47.

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