Drug Information

Drug General Information
Drug ID
D0P1AW
Former ID
DIB018772
Drug Name
AG14361
Synonyms
AG-14361; AG 14361
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527904]
Structure
Download
2D MOL
Formula
C19H20N4O
InChI
InChI=1S/C19H20N4O/c1-22(2)12-13-6-8-14(9-7-13)18-21-16-5-3-4-15-17(16)23(18)11-10-20-19(15)24/h3-9H,10-12H2,1-2H3,(H,20,24)
InChIKey
SEKJSSBJKFLZIT-UHFFFAOYSA-N
PubChem Compound ID
9840076
PubChem Substance ID
14801398, 24138480, 44938160, 49645682, 75980483, 99431558, 99460875, 103261452, 104015396, 104253502, 124757624, 124792817, 125164428, 136340148, 136920261, 137275824, 140105717, 152258354, 160647192, 162011827, 162037796, 162202721, 163908012, 164194027, 165247593, 172649965, 174528919, 178118772, 179551797, 185990463, 198960971, 223396135, 223704418, 231943732, 247394852, 249565774, 251962950, 252109983, 252214684, 252436436
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Inhibitor [526503]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 527904The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res. 2005 Dec 1;11(23):8449-57.
Ref 526503Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors. J Med Chem. 2003 Jan 16;46(2):210-3.

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