Drug Information

Drug General Information
Drug ID
D06PAU
Former ID
DNC000091
Drug Name
5'-methylthioadenosine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [537937]
Structure
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2D MOL

3D MOL
Formula
C11H15N5O3S
Canonical SMILES
CSCC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O
InChI
1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)
InChIKey
WUUGFSXJNOTRMR-UHFFFAOYSA-N
CAS Number
CAS 2457-80-9
PubChem Compound ID
149
PubChem Substance ID
125788, 440424, 440427, 460119, 4287320, 8150479, 10515352, 24438526, 26758561, 49865132, 57319992, 75281322, 103809281, 104293988, 117523304, 118270549, 124590042, 125678566, 129637315, 134982230, 137176354, 137376253, 141167160, 162550413, 163688277, 227158283, 241204839
ChEBI ID
ChEBI:17509
Target and Pathway
Target(s) Cysteinyl leukotriene receptor 1 Target Info Antagonist [537937]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
IL4 Signaling Pathway
IL3 Signaling Pathway
Pathway Interaction Database Endothelins
Reactome Leukotriene receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 537937Inhibition of the tyrosine kinase activity of the fibroblast growth factor receptor by the methyltransferase inhibitor 5'-methylthioadenosine. J Biol Chem. 1993 Feb 25;268(6):4244-9.
Ref 537937Inhibition of the tyrosine kinase activity of the fibroblast growth factor receptor by the methyltransferase inhibitor 5'-methylthioadenosine. J Biol Chem. 1993 Feb 25;268(6):4244-9.

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