Drug Information

Drug General Information
Drug ID
D0F1UL
Former ID
DAP001205
Drug Name
Dydrogesterone
Synonyms
Dehydrogesterone; Didrogesterona; Didrogesterone; Diphaston; Dufaston; Duphaston; Duvaron; Dydrogesterona; Dydrogesteronum; Gestatron; Gynorest; Hydrogesterone; Hydrogestrone; Isopregnenone; Prodel; Retrone; Terolut; Didrogesterone [DCIT]; Solvay Brand of Dydrogesterone; DELTA6-Retroprogesterone; Duphaston (TN); Dydrogesterona [INN-Spanish]; Dydrogesteronum [INN-Latin]; Gynorest (TN); Delta(6)-Retroprogesterone; Delta(sup 6)-Retroprogesterone; Retro-6-dehydroprogesterone; Dydrogesterone (JP15/USP/INN); Dydrogesterone [USAN:INN:BAN:JAN]; Pregna-4,6-diene-3,20-dione, (9-beta,10-alpha)-(9CI); (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one; (9-beta,10-alpha)-Pregna-4,6-diene-3,20-dione; (9beta,10alpha)-pregna-4,6-diene-3,20-dione; 10alpha-Isopregnenone; 6 Dehydro 9 beta 10 alpha progesterone; 6-Dehydro-9 beta-10 alpha-progesterone; 6-Dehydro-9.beta.,10.alpha.-progesterone; 6-Dehydro-9beta,10alpha-progesterone; 6-Dehydro-retro-progesterone; 6-Dehydroretroprogesterone; 9-.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9-beta,10-alpha-Pregna-4,6-diene-3,20-dione; 9-beta,10alpha-Pregna-4,6-diene-3,20-dione; 9.beta.,10.alpha.-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione; 9beta,10alpha-Pregna-4,6-diene-3,20-dione (8CI)
Drug Type
Small molecular drug
Indication Menstrual disorders [ICD9: 626; ICD10:N91-N95] Approved [539904], [550691]
Therapeutic Class
Progesterones
Company
Solvay Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C21H28O2
InChI
InChI=1S/C21H28O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h4-5,12,16-19H,6-11H2,1-3H3/t16-,17+,18-,19+,20+,21+/m0/s1
InChIKey
JGMOKGBVKVMRFX-HQZYFCCVSA-N
CAS Number
CAS 152-62-5
PubChem Compound ID
9051
PubChem Substance ID
398384, 7848280, 7979141, 8156439, 11466699, 11467819, 11486418, 14898944, 15444771, 29227669, 46506195, 47365375, 47736654, 47736655, 48259427, 48415933, 49699132, 50019401, 50124160, 50751954, 53787025, 56394852, 56463092, 57325399, 71822875, 85788500, 87325136, 92125727, 103770836, 103914481, 104319423, 121363398, 124799336, 126653040, 126667084, 128271591, 134338445, 134973758, 135650214, 137005553, 139642162, 144203980, 152034951, 160963725, 162177763, 164178107, 170465104, 175611963, 179149345, 184546093
ChEBI ID
ChEBI:31527
SuperDrug ATC ID
G03DB01
SuperDrug CAS ID
cas=000152625
Target and Pathway
Target(s) Progesterone receptor Target Info Agonist [536560]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 539904(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2878).
Ref 550691Drug information of Dydrogesterone, 2008. eduDrugs.
Ref 536560Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile. Steroids. 2008 Feb;73(2):222-31.Epub 2007 Oct 22.

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