Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0O3YF
|
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| Former ID |
DAP000014
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| Drug Name |
Cyclosporine
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| Synonyms |
CSA; Ciclosporin; Consupren; Cyclokat; Cyclophorine; Cyclosporin; Equoral; Gengraf; Mitogard; Neoplanta; Neoral; NeuroSTAT; Papilock; Pulminiq; Restasis; Sandimmun; Sandimmune; SangCyA; Sigmasporin; Vekacia; Zyclorin; Cipol N; Consupren S; Cyclosporin A; Cyclosporin A Implant; Cyclosporine A; Cyclosporine [USAN]; RamihyphinA; Sandimmun Neoral; Sigmasporin Microoral; Antibiotic S 7481F1; C 3662; Cicloral (TN); Ciclosporin (JP15); Cipol-N; Cyclosporin A, Tolypocladium inflatum; Cyclosporine (USP); DE-076; From Tolypocladium inflatum (Trichoderma polysporin); Gengraf (TN); Modusik-A; Neoral (TN); Nova-22007; OL 27-400; OL-27400; OLO-400; Restasis (TN); S-Neoral; SDZ-OXL 400; ST-603; Sandimmune (TN); Sang-2000; Sang-35; TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A); CB-01-09 MMX; CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)); CsA & IFN-alpha; Cyclosporin A & IFN-alpha; GNF-Pf-2808; Helv Chim Acta 60: 1568 (1977); Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine; BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA; BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA; CsA
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| Therapeutic Class |
Immunosuppressive Agents
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| Company |
Sandoz
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| Structure |
|
Download2D MOL |
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| Formula |
C62H111N11O12
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| Canonical SMILES |
CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C<br />(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)<br />O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C<br />)C)C
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| InChI |
1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+/t40-,41+,42+,43-,44+,45-,46+,47+,49+,50-,51+,52-/m1/s1
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| InChIKey |
PMATZTZNYRCHOR-VJRYSDSKSA-N
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| CAS Number |
CAS 59865-13-3
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| PubChem Compound ID | |||||
| PubChem Substance ID |
127280714, 127280715, 127280716, 127280717, 127280718, 127280719, 127280720, 127280721, 127280722, 127280723, 127280724, 127280725, 127280726, 127280727, 127280728, 127280729, 127280730, 127280731, 127280732, 127300898, 127300899, 127300900, 127300901, 127300902, 127300903, 127300904, 127300905, 127300906, 127300907, 127300908, 127300909, 127300910, 127300911, 127300912, 127300913, 127300914, 137018976, 226407640
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| ChEBI ID |
ChEBI:4031
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| SuperDrug ATC ID |
L04AD01; S01XA18
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| SuperDrug CAS ID |
cas=059865133
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| Target and Pathway | |||||
| Target(s) | Calcineurin | Target Info | Inhibitor | [536395] | |
| KEGG Pathway | MAPK signaling pathway | ||||
| Calcium signaling pathway | |||||
| cGMP-PKG signaling pathway | |||||
| Oocyte meiosis | |||||
| Apoptosis | |||||
| Wnt signaling pathway | |||||
| Axon guidance | |||||
| VEGF signaling pathway | |||||
| Osteoclast differentiation | |||||
| Natural killer cell mediated cytotoxicity | |||||
| T cell receptor signaling pathway | |||||
| B cell receptor signaling pathway | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Oxytocin signaling pathway | |||||
| Glucagon signaling pathway | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Amphetamine addiction | |||||
| Tuberculosis | |||||
| HTLV-I infection | |||||
| WikiPathways | Mitochondrial Gene Expression | ||||
| MAPK Signaling Pathway | |||||
| G Protein Signaling Pathways | |||||
| Cardiac Hypertrophic Response | |||||
| Fc epsilon receptor (FCERI) signaling | |||||
| Signaling by the B Cell Receptor (BCR) | |||||
| T-Cell Receptor and Co-stimulatory Signaling | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Spinal Cord Injury | |||||
| Alzheimers Disease | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| Opioid Signalling | |||||
| MicroRNAs in cardiomyocyte hypertrophy | |||||
| Physiological and Pathological Hypertrophy of the Heart | |||||
| References | |||||
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