Drug General Information
Drug ID	D0O9YG
Former ID	DNC000494
Drug Name	Cycloguanil
Drug Type	Small molecular drug
Indication	Malaria [ICD10:B54]		Investigative	[536135]
Structure		Download 2D MOL 3D MOL
Formula	C11H14ClN5
Canonical SMILES	CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C
InChI	1S/C11H14ClN5/c1-11(2)16-9(13)15-10(14)17(11)8-5-3-7(12)4-6-8/h3-6H,1-2H3,(H4,13,14,15,16)
InChIKey	QMNFFXRFOJIOKZ-UHFFFAOYSA-N
CAS Number	CAS 516-21-2
PubChem Compound ID	9049
PubChem Substance ID	602626, 6430954, 6440410, 8156438, 11382587, 14823479, 29227667, 46518846, 48415827, 50056269, 50241440, 57325397, 99206041, 99206044, 103200191, 104319417, 106184278, 126408547, 129044396, 131337632, 134339905, 134976109, 136903271, 136903274, 137006527, 137174062, 140329280, 170494913, 179148262, 198941333, 198991512, 223519007, 224828293, 226507347, 249865570, 250134729
Target and Pathway
Target(s)	Dihydrofolate reductase	Target Info	Inhibitor	[536135]
PathWhiz Pathway	Folate Metabolism
	Pterine Biosynthesis
Reactome	E2F mediated regulation of DNA replication
	Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
	Metabolism of folate and pterines
	G1/S-Specific Transcription
References
Ref 536135	Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.
Ref 536135	Opportunities and challenges in antiparasitic drug discovery. Nat Rev Drug Discov. 2005 Sep;4(9):727-40.

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