Drug Information

Drug General Information
Drug ID
D02UUO
Former ID
DIB019743
Drug Name
dihydrosphingosine-1-phosphate
Synonyms
sphinganine 1-phosphate; sphinganine-phosphate; dihydroS1P
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539938]
Structure
Download
2D MOL
Formula
C18H40NO5P
InChI
InChI=1S/C18H40NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h17-18,20H,2-16,19H2,1H3,(H2,21,22,23)/t17-,18+/m0/s1
InChIKey
YHEDRJPUIRMZMP-ZWKOTPCHSA-N
PubChem Compound ID
644260
PubChem Substance ID
4351, 841940, 7850620, 8707331, 11119908, 11120396, 11120884, 11146991, 15299866, 24398003, 26754967, 43765961, 57408238, 75532773, 103280927, 104046553, 109827914, 126524013, 135650184, 135653455, 137161492, 138194667, 162249757, 163122702, 164840228, 179205496, 184528620, 204376673, 226554419, 248487227, 252321281
Target and Pathway
Target(s) S1P4 receptor Target Info Agonist [526430]
GPR63 Target Info Agonist [526565]
References
Ref 539938(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2921).
Ref 526430Phytosphingosine 1-phosphate: a high affinity ligand for the S1P(4)/Edg-6 receptor. Biochem Biophys Res Commun. 2002 Sep 27;297(3):600-6.
Ref 526565Sphingosine 1-phosphate and dioleoylphosphatidic acid are low affinity agonists for the orphan receptor GPR63. Cell Signal. 2003 Apr;15(4):435-46.

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