Drug Information

Drug General Information
Drug ID
D05YYO
Former ID
DIB018263
Drug Name
[3H]clidinium
Synonyms
[3H](-)N-methyl-3-quinuclidinyl benzilate; Ro-23773; (-)MQNB
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540447]
Structure
Download
2D MOL
Formula
C22H26NO3+
InChI
InChI=1S/C22H26NO3/c1-23-14-12-17(13-15-23)20(16-23)26-21(24)22(25,18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-11,17,20,25H,12-16H2,1H3/q+1
InChIKey
HOOSGZJRQIVJSZ-UHFFFAOYSA-N
PubChem Compound ID
2784
PubChem Substance ID
10055, 5527706, 5864563, 7978960, 8151796, 10544421, 11335873, 11361112, 11363050, 11365612, 11368174, 11371367, 11373981, 11376336, 11462084, 11466850, 11467970, 11483904, 11486400, 11487940, 11490170, 11492106, 11493970, 29221939, 46507814, 47291148, 47365199, 47365200, 47589012, 47662296, 48259241, 48334503, 49698978, 50807214, 57321458, 85209725, 96079550, 103188114, 103952426, 104301601, 124883402, 128485066, 134222992, 134338362, 135077135, 135650108, 135651180, 135950079, 137260982, 141696484
Target and Pathway
Target(s) Muscarinic receptor Target Info Antagonist [534549]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Cholinergic synapse
Regulation of actin cytoskeleton
PathWhiz Pathway Muscle/Heart Contraction
Reactome Muscarinic acetylcholine receptors
Acetylcholine regulates insulin secretion
G alpha (q) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
Regulation of Actin Cytoskeleton
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Secretion of Hydrochloric Acid in Parietal Cells
GPCR ligand binding
GPCR downstream signaling
References
Ref 540447(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 351).
Ref 534549Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line. J Pharmacol Exp Ther. 1998 Feb;284(2):500-7.

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