Drug General Information
Drug ID	D03LRY
Former ID	DNC012761
Drug Name	C-(6-Methoxy-naphthalen-1-yl)-methylamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[534531]
Structure		Download 2D MOL 3D MOL
Formula	C12H13NO
Canonical SMILES	COC1=CC2=C(C=C1)C(=CC=C2)CN
InChI	1S/C12H13NO/c1-14-11-5-6-12-9(7-11)3-2-4-10(12)8-13/h2-7H,8,13H2,1H3
InChIKey	HOVVWANIDLIBGI-UHFFFAOYSA-N
PubChem Compound ID	44352202
Target and Pathway
Target(s)	Alpha-2B adrenergic receptor	Target Info	Inhibitor	[534531]
	Alpha-2A adrenergic receptor	Target Info	Inhibitor	[534531]
	Alpha-2C adrenergic receptor	Target Info	Inhibitor	[534531]
KEGG Pathway	cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway
	Neuroactive ligand-receptor interaction
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathwayP00002:Alpha adrenergic receptor signaling pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Reactome	Adrenoceptors
	Adrenaline signalling through Alpha-2 adrenergic receptor
	G alpha (i) signalling events
	G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors
	Adrenaline,noradrenaline inhibits insulin secretion
	G alpha (z) signalling events
	Surfactant metabolismR-HSA-390696:Adrenoceptors
	Surfactant metabolism
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Platelet Aggregation (Plug Formation)
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
References
Ref 534531	J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
Ref 534531	J Med Chem. 1997 Dec 5;40(25):3997-4005.Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.