Drug Information

Drug General Information
Drug ID
D01TDR
Former ID
DIB019641
Drug Name
corticosterone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539894]
Structure
Download
2D MOL
Formula
C21H30O4
InChI
InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChIKey
OMFXVFTZEKFJBZ-HJTSIMOOSA-N
PubChem Compound ID
5753
PubChem Substance ID
5219, 75084, 804393, 841767, 855741, 6435953, 7886418, 7978988, 8143631, 8153530, 10321632, 11466460, 11467580, 11486119, 17389502, 17404783, 24278302, 24856812, 24869860, 25630774, 26751495, 26758495, 29224789, 46386953, 46504547, 47275526, 47646532, 48018879, 48243330, 48318377, 48393901, 48393902, 48421980, 48424986, 49698488, 49956045, 50104040, 53777326, 53788667, 53834312, 56311825, 56312404, 56312772, 56313244, 56423132, 57322931, 57390013, 57648276, 57650717, 58685480
Target and Pathway
Target(s) mRNA of glucocorticoid receptor Target Info Agonist [525736]
KEGG Pathway Neuroactive ligand-receptor interaction
NetPath Pathway IL2 Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by HDAC Class II
FOXA2 and FOXA3 transcription factor networks
Glucocorticoid receptor regulatory network
Regulation of Androgen receptor activity
AP-1 transcription factor network
Reactome BMAL1:CLOCK,NPAS2 activates circadian gene expression
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
SIDS Susceptibility Pathways
Endoderm Differentiation
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Adipogenesis
Circadian Clock
Nuclear Receptors
References
Ref 539894(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2869).
Ref 525736Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding. J Biol Chem. 2000Jun 23;275(25):19041-9.

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