Drug Information

Drug General Information
Drug ID
D06YEV
Former ID
DNC002580
Drug Name
Hydroxydimethylarsine Oxide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C2H7AsO2
Canonical SMILES
C[As](=O)(C)O
InChI
1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)
InChIKey
OGGXGZAMXPVRFZ-UHFFFAOYSA-N
PubChem Compound ID
2513
PubChem Substance ID
9516, 405276, 550112, 583643, 585540, 609263, 820929, 820955, 825024, 825305, 825315, 825331, 826127, 828436, 830633, 830847, 830886, 831497, 833146, 854580, 855157, 3152853, 5070549, 6436179, 8018167, 8022881, 8023029, 8027709, 8027881, 8028368, 8150092, 8151668, 10317216, 10317237, 10534914, 11335883, 11361122, 11364913, 11367475, 11370037, 11374068, 11378207, 11404479, 11405987, 11447883, 11447931, 11449379, 11462094, 11484895, 11488986
Target and Pathway
Target(s) Nitric-oxide synthase, endothelial Target Info Inhibitor [551393]
Aldose reductase Target Info Inhibitor [551393]
BioCyc Pathway Citrulline-nitric oxide cyclePWY-5453:Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Arginine and proline metabolism
Metabolic pathways
Calcium signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Platelet activation
Estrogen signaling pathway
Oxytocin signaling pathwayhsa00040:Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
NetPath Pathway Wnt Signaling PathwayNetPath_13:IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Angiogenesis
Endothelin signaling pathway
Interleukin signaling pathway
PI3 kinase pathway
VEGF signaling pathway
Pathway Interaction Database Plasma membrane estrogen receptor signaling
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Angiopoietin receptor Tie2-mediated signaling
Thromboxane A2 receptor signaling
SHP2 signaling
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
PAR1-mediated thrombin signaling events
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
Reactome ROS production in response to bacteria
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
eNOS activation
Nitric oxide stimulates guanylate cyclase
VEGFR2 mediated vascular permeability
WikiPathways ACE Inhibitor Pathway
EGF/EGFR Signaling Pathway
Myometrial Relaxation and Contraction Pathways
JAK/STAT
Corticotropin-releasing hormone
AGE/RAGE pathway
Endothelin Pathways
Leptin signaling pathway
Effects of Nitric Oxide
Metabolism of nitric oxide
AngiogenesisWP702:Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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