Drug General Information
Drug ID	D03KQG
Former ID	DNC012069
Drug Name	Pyrrolidin-1-yl-thiourea
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[527001]
Structure		Download 2D MOL 3D MOL
Formula	C5H11N3S
Canonical SMILES	C1CCN(C1)NC(=S)N
InChI	1S/C5H11N3S/c6-5(9)7-8-3-1-2-4-8/h1-4H2,(H3,6,7,9)
InChIKey	LUZJFNYVKQEEGM-UHFFFAOYSA-N
PubChem Compound ID	44291858
Target and Pathway
Target(s)	Vanilloid receptor	Target Info	Inhibitor	[527001]
	Vanilloid receptor 1	Target Info	Inhibitor	[527001]
	Transient receptor potential cation channel subfamily V member 4	Target Info	Inhibitor	[527001]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channelshsa04750:Inflammatory mediator regulation of TRP channels
NetPath Pathway	IL2 Signaling Pathway
Pathway Interaction Database	Trk receptor signaling mediated by the MAPK pathway
	Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome	TRP channelsR-HSA-3295583:TRP channels
References
Ref 527001	Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.
Ref 527001	Bioorg Med Chem Lett. 2004 Apr 5;14(7):1693-6.N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.

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