TTD | Drug: D0JQ1D

Drug General Information
Drug ID	D0JQ1D
Former ID	DIB020820
Drug Name	Ro 41-5253
Synonyms	Ro-415253; Ro415253; LG629
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[539708]
Structure		Download 2D MOL
Formula	C28H36O5S
InChI	InChI=1S/C28H36O5S/c1-5-6-7-8-9-15-33-25-19-26-24(28(3,4)14-16-34(26,31)32)18-23(25)20(2)17-21-10-12-22(13-11-21)27(29)30/h10-13,17-19H,5-9,14-16H2,1-4H3,(H,29,30)/b20-17+
InChIKey	JEIWQRITHXYGIF-LVZFUZTISA-N
PubChem Compound ID	5312120
PubChem Substance ID	7979398, 11056886, 14834962, 39341740, 53789717, 75612557, 114157921, 135074759, 135650918, 140189451, 142518527, 223717686, 230135672, 230135675
Target and Pathway
Target(s)	Retinoic acid receptor alpha	Target Info	Antagonist	[526743]
KEGG Pathway	Pathways in cancer
	Transcriptional misregulation in cancer
	Acute myeloid leukemia
Pathway Interaction Database	Retinoic acid receptors-mediated signaling
Reactome	Nuclear Receptor transcription pathway
WikiPathways	Vitamin A and Carotenoid Metabolism
	Nuclear Receptors in Lipid Metabolism and Toxicity
	Integrated Pancreatic Cancer Pathway
	Adipogenesis
	Nuclear Receptors
References
Ref 539708	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2642).
Ref 526743	A retinoic acid receptor alpha antagonist selectively counteracts retinoic acid effects. Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):7129-33.

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Drug Information