Drug Information

Drug General Information
Drug ID
D0M0YH
Former ID
DIB019864
Drug Name
fMet-Leu-Phe
Synonyms
fMetLeuPhe; formyl-Met-Leu-Phe
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538625]
Structure
Download
2D MOL
Formula
C21H31N3O5S
InChI
InChI=1S/C21H31N3O5S/c1-14(2)11-17(23-19(26)16(22-13-25)9-10-30-3)20(27)24-18(21(28)29)12-15-7-5-4-6-8-15/h4-8,13-14,16-18H,9-12H2,1-3H3,(H,22,25)(H,23,26)(H,24,27)(H,28,29)/t16-,17-,18-/m0/s1
InChIKey
PRQROPMIIGLWRP-BZSNNMDCSA-N
PubChem Compound ID
443295
PubChem Substance ID
13761, 7979309, 10299271, 15255880, 24871354, 24894846, 36886639, 50076428, 53788451, 56323719, 57404334, 57651094, 76715943, 81067114, 87246508, 91697294, 93576761, 103165446, 103948030, 104629627, 124801087, 127320376, 127320377, 128958529, 134344725, 135652157, 135697809, 137019908, 140715047, 144224142, 160654666, 162220825, 164756522, 179316750, 184562936, 226424894, 241375691, 252156187, 252360975
Target and Pathway
Target(s) FMLP-related receptor I Target Info Agonist [533990]
FMLP receptor Target Info Agonist [533579]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Staphylococcus aureus infection
NetPath Pathway Leptin Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome G alpha (q) signalling events
G alpha (i) signalling eventsR-HSA-418594:G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
Human Complement System
GPCR downstream signaling
References
Ref 538625(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1022).
Ref 533579Further studies on the structural requirements for synthetic peptide chemoattractants. Biochemistry. 1980 May 27;19(11):2404-10.
Ref 533990Multiple domains of the N-formyl peptide receptor are required for high-affinity ligand binding. Construction and analysis of chimeric N-formyl peptide receptors. J Biol Chem. 1993 Aug 25;268(24):18167-75.

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