Drug Information

Drug General Information
Drug ID
D03WTU
Former ID
DIB021043
Drug Name
TG4-155
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541136]
Structure
Download
2D MOL
Formula
C23H26N2O4
InChI
InChI=1S/C23H26N2O4/c1-16-13-18-7-5-6-8-19(18)25(16)12-11-24-22(26)10-9-17-14-20(27-2)23(29-4)21(15-17)28-3/h5-10,13-15H,11-12H2,1-4H3,(H,24,26)/b10-9+
InChIKey
YBHUXHFZLMFETJ-MDZDMXLPSA-N
PubChem Compound ID
5886965
PubChem Substance ID
17515129, 39621646, 74396463, 97168382, 97314496, 106363992, 114228026, 124803350, 163482588, 178102443, 179510445, 239315517, 242041716, 242178640, 252158562, 252450275, 252543609
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Antagonist [531794]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541136(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5818).
Ref 531794Small molecule antagonist reveals seizure-induced mediation of neuronal injury by prostaglandin E2 receptor subtype EP2. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3149-54.

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